Advances in the research of sperm protein 17.
- Author:
Ling ZHANG
1
;
Fangqiu LI
Author Information
1. Center of Medical Laboratory Science of PLA, Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antigens, Surface;
Carrier Proteins;
analysis;
physiology;
Contraception, Immunologic;
Humans;
Immunotherapy;
Male
- From:
National Journal of Andrology
2004;10(4):295-301
- CountryChina
- Language:Chinese
-
Abstract:
Sperm protein 17 (Sp17) is a testis-specific protein involved in acrosome reaction in spermatozoa. However, the Sp17 gene has been recently detected in normal non-testis tissues and malignant neoplasias. Therefore Sp17 may be a potential target for immunocontraception and a suitable target for tumor immunotherapy. This paper reviews the advances in the protein characterization, expression and distribution, and biological function of Sp17 and its clinical research.
