Clinical significance of six-transmembrane epithelial antigen of the prostate expressed in prostatic carcinoma.
- Author:
Liaoyuan LI
1
;
Jiefang LI
;
Zhoujun SHEN
;
Weijun LIU
;
Zhaodian CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, Neoplasm; analysis; genetics; Humans; Immunohistochemistry; Male; Oxidoreductases; Prostatic Neoplasms; diagnosis; immunology; pathology
- From: National Journal of Andrology 2004;10(5):351-354
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between six-transmembrane epithelial antigen of the prostate (STEAP) expression and the histologic grading of prostatic carcinoma (PCa).
METHODSDifferent prostatic tissues and non-prostatic tumors, 131 cases of PCa, 164 cases of benign prostate hyperplasia (BPH), and 56 cases of non-prostatic malignancies, were analyzed for the expression of STEAP by using STEAP monoclonal antibody and SP immunohistochemical staining. The positive area unit (PU) was introduced to describe the intensity of STEAP expression.
RESULTSThe prostatic tissues of all but 3 cases of PCa and 5 cases of BPH were stained positively, while all of the non-prostatic tumors were stained negatively. There was a significant negative correlation between the STEAP expression and the histologic grading of PCa.
CONCLUSIONSTEAP can be a prognostic marker of PCa and a potential therapeutic target in PCa.
