Experimental research on tea saponin ameliorating nonoxynol spermicidal action in vitro.
- Author:
Zhengyi WANG
1
;
Youming ZHENG
;
Kai GUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Synergism; Male; Nonoxynol; pharmacology; Rabbits; Saponins; pharmacology; Spermatocidal Agents; pharmacology; Tea
- From: National Journal of Andrology 2004;10(5):397-399
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of tea saponin in ameliorating nonoxynol(N-9) spermicidal action in vitro.
METHODSAccording to the improved spermicidal test method in vitro recommended by International Planned Parenthood Foundation (IPPF), we evaluated the minimum spermicidal concentration of N-9, tea saponin and their mixed solution in 20 s and 3 min.
RESULTSThe minimum spermicidal concentration of N-9 in the mixed solution was (0.13 +/- 0.05) g/L in 20 s and (0.05 +/- 0.004) g/L in 3 min, and that of the tea saponin in the mixed solution was (2.40 +/- 1.07) g/L in 20 s and (1.27 +/- 0.38) g/L in 3 min, compared with the single ingredient N-9 [(0.48 +/- 0.15) g/L in 20 s, (0.34 +/- 0.079 g/L in 3 min], and tea saponin [(5.78 +/- 1.40) g/L in 20 s, (1.71 +/- 0.176) g/L in 3 min], P < 0.01.
CONCLUSIONTea saponin can improve N-9 spermicidal action in vitro, and tea saponin and nonoxynol have proved of synergic effect.
