Effects of experimental varicocele on mitochondria calcium and cytochrome C of the epididymis in adolescent rats.
- Author:
Xiaoru MA
1
;
Shuqiu WANG
;
Yuexin WANG
;
Shuxiang WANG
;
Weiqun WANG
;
Jianhua ZHANG
;
Yongyi LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Calcium; metabolism; Cytochromes c; analysis; Epididymis; metabolism; Infertility, Male; etiology; Male; Mitochondria; metabolism; Rats; Rats, Wistar; Varicocele; metabolism
- From: National Journal of Andrology 2004;10(6):420-422
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of experimental varicocele on mitochondria calcium and cytochrome C of the epididymal cells in adolescent rats.
METHODSForty male adult Wistar rats were divided into two groups randomly: varicocele group (VG) and sham operation group (SOG) by partial ligation or exposure of the left renal vein. Bilateral epididymides were removed after ten
RESULTSThe content of mitochondria weeks. Mitochondria calcium and cytochrome C levels of the epididymal cells were detected. calcium decreased (P < 0.001 ) while that of cytochrome C increased (P < 0.05) markedly in the experimental group compared with SOG.
CONCLUSIONCalcium dyshomeostasis and mitochondrial damage of the epididymal cells caused by varicocele may play an important role in leading to subfertility.