Detection and potential function of anti-FSH antibodies in patients with spermatogenesis dysfunction.
- Author:
Bing YAO
1
;
Leilei ZHANG
;
Yingxia CUI
;
Yongmei WANG
;
Yufeng HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies; blood; Follicle Stimulating Hormone; immunology; Humans; Infertility, Male; etiology; immunology; Male; Spermatogenesis
- From: National Journal of Andrology 2004;10(7):491-495
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the anti-FSH antibody using ELISA, and further probe into the role of anti-FSH in infertile patients.
METHODSThe anti-FSH antibody was detected using ELISA in the serum of patients with spermatogenesis dysfunction, of infertile patients with normal sperm density and motility, and of normal fertile males.
RESULTSThe positive rate of anti-FSH antibody in the patients with oligospermia and/or asthenospermia [22.4% (22/98)] was significantly higher than that in the normal fertile [4% (2/50)] (P < 0.05) and that in the infertile patients with normal sperm density and motility [6.7% (2/30)] (P < 0.05). The positive rate of anti-FSH antibody in the patients with oligospermia and/or asthenospermia was lower than that in the patients with azoospermia [54.5% (12/22)] (P < 0.05). There was no significant difference in the positive rate between the normal control and the sterile males with normal sperm density and motility.
CONCLUSIONThe anti-FSH antibody may be an important factor to cause spermatogenesis dysfunction by combining FSH to form immune compound and depress the activation of FSH.
