Effect and mechanism of alpha1-adrenoceptor blocker combined with antibiotics for chronic prostatitis.

Baihua Shen; Xiaodong Jin; Songliang Cai; Jun Chen; Geming Chen; Weiping Zhao; Xin Sun

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Effect and mechanism of alpha1-adrenoceptor blocker combined with antibiotics for chronic prostatitis.

Author: Baihua SHEN ¹ ; Xiaodong JIN ; Songliang CAI ; Jun CHEN ; Geming CHEN ; Weiping ZHAO ; Xin SUN
Author Information

1. Department of Urology, the First Affiliated Hospital, Zhejiang University Medical College, Hangzhou, Zhejiang 310003, China. shen_bh@sina.com
Publication Type:Clinical Trial
MeSH: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; administration & dosage; Adult; Anti-Bacterial Agents; administration & dosage; Chronic Disease; Drug Therapy, Combination; Humans; Male; Middle Aged; Prostatitis; drug therapy; physiopathology; Urodynamics
From: National Journal of Andrology 2004;10(7):518-520
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the effect and mechanism of alpha1-adrenoceptor blocker combined with antibiotics in the treatment of chronic prostatitis.
METHODSEighty patients with chronic prostatitis were divided into two groups, one treated with alpha1-adrenoceptor blocker (Terazosin 2 mg qn) and Levo-ofloxacin (0.2 bid), and the other given Levo-ofloxacin (0.2 bid) alone for 6 weeks. Chronic prostatitis symptom index (CPSI), urodynamic data and prostatic secretion examination were compared before and after treatment.
RESULTSThe CPSI score of the treated group decreased from 31.8 +/- 7.4 to 15.5 +/-6.6, while that of the control group decreased from 30.9 +/- 7.1 to 21.4 +/- 6.2. There was significant difference between the two groups (P < 0.05). The maximum flow rates before and after the combined treatment were 16.5 +/- 6.3 ml/s and 20.4 +/- 4.6 ml/s, while those before and after Levo-ofloxacin administration were 16.1 +/-5.8 ml/s and 17.3 +/- 6.8 ml/s. The difference was significant (P < 0.05). The maximum urethral pressure of the combined treatment group decreased from 92.5 +/- 15.3 cm H2O to 72.5 +/- 13.4 cm H2O, while that of the control group decreased from 93.2 +/- 14.8 cm H2O to 91.7 +/- 13.6 cm H2O.
CONCLUSIONAlpha1-adrenoceptor blocker can lower the intraurethral pressure, which prevents urine from refluxing to the prostate. Alpha1-adrenoceptor blocker combined with antibiotics is effective for chronic prostatitis.