Study of the effect of super painkiller on the sexual function of male rats with type I diabetes.
- Author:
Baixin WANG
1
;
Shuqiu WANG
;
Shuxiang WANG
;
Yanhua GAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diabetes Mellitus, Type 1; complications; Drugs, Chinese Herbal; therapeutic use; Male; Nitric Oxide; analysis; Nitric Oxide Synthase; analysis; Rats; Rats, Wistar; Sexual Dysfunctions, Psychological; drug therapy
- From: National Journal of Andrology 2004;10(7):521-523
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of super painkiller on the sexual function of male Wistar rats with diabetes.
METHODSThirty-two Wistar rats at 3-5 months of age were divided into two groups at random: 22 in the diabetes group, and 10 in the control group. After 72 hours, the former was further divided into 2 subgroups: non-treatment and super painkiller treatment. In 5 weeks, blood glucose was determined. After the apomorphines experiment, the rats were killed, blood taken from the vein, homogenate prepared from the isolated testis tissue and the level of NO and NOS in the serum and tissue homogenate surveyed, separately.
RESULTSCompared with the control group, serum NO and NOS of the diabetic rats dropped sharply. Compared with the non-treatment group, the serum NO and NOS of the super painkiller treatment group were very high and the difference was significant (P < 0.01). Apomorphine injection showed that the times of penis erection of the treated rats were more than those of the non-treatment group (P < 0.01) , but the difference was not significant compared with the control (P > 0.05).
CONCLUSIONSuper painkiller has sure effect of reducing blood glucose, with a certain curative value for sexual and reproductive malfunction of diabetic rats.
