Early diagnosis of prostate cancer using free/total prostate-specific antigen ratio with population-based screening data.
- Author:
Ling ZHANG
1
;
Guoyi JI
;
Xiaomeng LI
;
Weihua WANG
;
Hongwen GAO
;
Yuzhuo PAN
;
Hongjun WANG
;
Kuwahara MASAAKI
;
Xuejian ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Area Under Curve; Early Diagnosis; Humans; Male; Mass Screening; Middle Aged; Prospective Studies; Prostate-Specific Antigen; blood; Prostatic Neoplasms; diagnosis; Sensitivity and Specificity
- From:National Journal of Andrology 2004;10(8):582-585
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the use of free/total prostate-specific antigen ratio (fPSA/tPSA ratio) in improving the early diagnosis of prostate cancer.
METHODSfPSA/tPSA ratio in the serum was analyzed prospectively in 187 men with tPSA ranging between 4.0 and 20.0 microg/L. All of them underwent ultrasound-guided sextant prostatic biopsies. Sensitivity, specificity, positive and negative predictive values were calculated by SPSS 10.0 software.
RESULTSProstate cancer detection rates were 18.1% and 22.5% when tPSA was within the ranges of 4.0-10.0 g/L and 10.0-20.0 g/L respectively. fPSA/tPSA ratio was more significant than tPSA in all the men. When the cut-off value of fPSA/tPSA ratio was set at 0.25, 90.5% and 87.5% of cancers could be detected; and 26.7% and 11.3% of biopsies could be avoided within the tPSA ranges of 4.0-10.0 g/L and 10.0-20.0 g/L, respectively.
CONCLUSIONThe use of fPSA/tPSA ratio can improve prostate cancer detection and reduce unnecessary biopsies when tPSA is within the range of 4.0-10.0 microg/L and 10.0-20.0 microg/L.
