Applied study on small-dose growth hormone supplement for aging-related symptom complex.
- Author:
Xiansheng ZHANG
1
;
Yixin WANG
;
Zheng LI
;
Jing LENG
;
Qiang BAI
;
Xuyuan HUANG
;
Yiran HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aging, Premature; drug therapy; Andropause; Blood Glucose; metabolism; Follow-Up Studies; Growth Hormone; administration & dosage; Humans; Insulin-Like Growth Factor I; metabolism; Lipids; blood; Male; Middle Aged; Prostate-Specific Antigen; blood
- From:National Journal of Andrology 2004;10(8):601-607
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the response of aging-related symptom complex to small-dose supplement of growth hormone.
METHODSThirty patients, aged 42 to 77, with aging-related symptom complex and normal serum testosterone were studied. Each subject received growth hormone at the dosage of 0.04 U/kg, 3 times/week for six months. Before and after treatment, body weight, grip strength, abdomen circumference, IPSS, uroflow rate, prostate volume, serum testosterone, cholesterol, triglyceride, PSA, IGF-1, glucose and side effects were determined in every case. Self Rating Scale used by Bosphorus university was adopted.
RESULTSAfter the treatment, the rating scores were significantly improved, grip strength and serum level of IGF-1 increased, and abdomen circumference and serum cholesterol decreased. Whereas, IPSS, uroflow rate, prostate volume, serum testosterone, triglyceride, PSA, glucose and body weight were not significantly changed.
CONCLUSIONSix months treatment with small-dose growth hormone can improve aging-related symptom complex with little adverse effect.
