Analysis of the relative etiology of non-obstructive azoospermia.
- Author:
Ling DUAN
1
;
Xiding ER
;
Jinping ZHAO
;
Lei DUAN
;
Qin LIU
;
Ruijun LIU
;
Chengjun WANG
;
Hong DU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Azoospermia; etiology; genetics; metabolism; Case-Control Studies; Chromosome Banding; Chromosomes, Human, Y; Epidermal Growth Factor; metabolism; Gonadal Steroid Hormones; metabolism; Humans; Male; Semen; chemistry; alpha-Glucosidases; metabolism
- From:National Journal of Andrology 2004;10(8):616-622
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the levels and changes of sexual hormone in serum and seminal plasma, and the epidermal growth factor (EGF), alpha-glucosidase, and fructose in the seminal plasma of non-obstructive azoospermic patients, and to assess the significance of the analysis of their chromosomes.
METHODSThirty-six non-obstructive azoospermic males and 26 normal males were chosen. The results in reproductive endocrine and genetics obtained by radioimmunoassay, colorimetry, and chromosomes G and C banding assay were compared and analyzed to explore into the causes of infertility.
RESULTSThe levels of FSH, LH, PRL and E2 in the serum of the non-obstructive azoospermic patients were higher than those of the control group, but the T level had no significant difference between the two groups. There were no obvious differences in the sexual hormones except in FSH of the seminal plasma. There were 2 cases of abnormal sex chromosomes, 2 cases of big Y chromosomes and 7 cases of small Y chromosomes in the non-obstructive azoospermic patients. No correlation was found between EGF and fructose in the seminal plasma.
CONCLUSIONThe level of sexual hormone in serum, alpha-glucosidase in seminal plasma and abnormal chromosomes might be closely related to non-obstructive azoospermia.
