Expression and significance of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer.
- Author:
Zhaohui CHEN
1
;
Yu YANG
;
Yajun XIAO
;
Jun ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blotting, Western; Cell Line, Tumor; HL-60 Cells; Humans; Immunohistochemistry; K562 Cells; Male; Prostatic Hyperplasia; metabolism; Prostatic Neoplasms; metabolism; pathology; Rabbits; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; biosynthesis
- From: National Journal of Andrology 2004;10(9):655-657
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression and significance of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in human prostate cancer.
METHODSSP immunohistochemical method was employed to investigate the expression of alpha subunit of GM-CSF receptors in 48 cases of primary prostate cancer, 20 benign prostate hyperplasia samples and four kinds of cancer cell lines K562, PC-3M, HL-60 and MCF-7.
RESULTSThe total positive percentage of GM-CSF expression in prostate cancer was 79.2%. The positive percentages in the groups with Gleason score 2-4, 5-8, and 9-10 were 75%, 82.3% and 81.2% respectively. The four kinds of cancer cell lines had prominent GM-CSF receptor alpha subunit expression.
CONCLUSIONIt suggests that both hyperplastic and neoplastic prostate tissues are responsive to GM-CSF and the extensive expression of GM-CSF receptors is an important characteristic of prostate cancer.
