Effects of Chinese herbal medicine Yiqi Huaju Formula on hypertensive patients with metabolic syndrome: a randomized, placebo-controlled trial.
- Author:
Yi CHEN
1
;
De-yu FU
;
Yu CHEN
;
Yan-ming HE
;
Xiao-dong FU
;
Yan-qiu XU
;
Yi LIU
;
Xiao-Tao FENG
;
Teng ZHANG
;
Wen-Jian WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Blood Glucose; metabolism; Blood Pressure; Drugs, Chinese Herbal; therapeutic use; Female; Glycated Hemoglobin A; metabolism; Humans; Hypertension; complications; drug therapy; metabolism; physiopathology; Lipids; blood; Male; Metabolic Syndrome; complications; drug therapy; metabolism; physiopathology; Middle Aged; Treatment Outcome; Young Adult
- From: Journal of Integrative Medicine 2013;11(3):184-194
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDPatients with hypertension coupled with metabolic syndrome (MetS) are among the high risk population in cardiovascular and cerebrovascular diseases. To reduce the prevalence of cardiovascular and cerebrovascular diseases, it is essential to appropriately control blood pressure together with other cardiovascular risk factors.
OBJECTIVEThe current study was designed to investigate the therapeutic effects on blood pressure, blood pressure variability and other cardiovascular risk factors by giving Yiqi Huaju Formula, a compound traditional Chinese herbal medicine, in addition to routine treatment to hypertensive patients coupled with MetS.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONSA total of 43 patients with hypertension coupled with MetS were recruited into this study. The enrolled patients were randomly divided into the Chinese herbal formula group (anti-hypertensive drugs plus Yiqi Huaju Formula, CHF) and the control group (anti-hypertensive drugs plus placebo). The CHF group enrolled 22 patients while the control group received 21 cases. Treatments were given for 12 weeks in both groups.
MAIN OUTCOME MEASURESParameters examined include 24-hour ambulatory blood pressure monitoring, body mass index, waist circumference, waist-to-hip ratio, homeostatic model assessment for insulin resistance (HOMA-IR), fasting glycosylated hemoglobin (HbA1c), fasting plasma glucose, 2-hour postprandial plasma glucose (PPG), fasting plasma insulin, serum lipid, etc.
RESULTSCompared with the control group, the CHF group had significant improvement (P<0.01) in anthropometric parameters, FPG, HOMA-IR, blood pressure amplitude, blood pressure variability and blood pressure load.
CONCLUSIONThis study showed that integrated traditional Chinese and Western medicine treatment can achieve better results in controlling blood pressure as well as other cardiovascular risk factors. The mechanism of controlling of blood pressure may be associated with the improvement of insulin sensitivity due to the Yiqi Huaju intervention. TRIAL REGISTRATION IDENTIFIER: ChiCTR-TRC-11001633.
