A new vomiting animal model--mink.
- Author:
Wang YUE
1
;
Fang ZHANG
;
Lei WANG
;
Xuan FANG
;
Yan-xia LIU
;
Masaru MINAMI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antiemetics; therapeutic use; Apomorphine; Cisplatin; Copper Sulfate; Disease Models, Animal; Male; Metoclopramide; therapeutic use; Mink; Ondansetron; therapeutic use; Vomiting; chemically induced; drug therapy
- From: Acta Pharmaceutica Sinica 2003;38(2):89-91
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo establish a new, reliable vomiting model in minks.
METHODSAdult male minks (Mustela vison) were randomly divided into groups (n = 6). Cisplatin, apomorphine, copper sulfate and X-radiation were used to establish vomiting model. Retching and vomiting were observed after the vomiting models were given anti-vomiting agents. After the behavioral experiment, assay of 5-HT in the ileum was performed by immunohistologic method.
RESULTSCisplatin 7.5 mg.kg-1 i.p., apomorphine 1.6 mg.kg-1 s.c. and copper sulfate 40 mg.kg-1 ig were shown to evoke vomiting. Retching and vomiting were significantly inhibited in ondansetron and metoclopramide pretreated minks (P < 0.05, P < 0.01).
CONCLUSIONAs a new vomiting model, minks may be of great value in studying vomiting mechanism and screening new antiemetic drugs.
