Clinical and laboratory features of preleukemia patients.
- Author:
Jun SHI
1
;
Zonghong SHAO
;
Guibin CHEN
;
Ke LI
;
Hong LIU
;
Yizhi ZHANG
;
Hong HE
;
Mingfeng ZHAO
;
Guangsheng HE
;
Hong ZHANG
;
Yulin CHU
;
Yushu HAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Apoptosis; Case-Control Studies; Chromosome Aberrations; Female; Humans; Immunophenotyping; Male; Middle Aged; Preleukemia; diagnosis; genetics; pathology; Survival Rate
- From: Chinese Medical Journal 2002;115(1):3-7
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore prospective diagnostic criteria for preleukemia.
METHODSA case control study was done comparing the discrepancies on clinical and laboratory features between patients with preleukemia and those with chronic aplastic anemia (CAA) or atypical paroxysmal nocturnal hemoglubinuria (a-PNH).
RESULTSThere were eight variables of significance: (1) lymphocytoid micromegakaryocytes in the bone marrow; (2) immature granulocytes in the peripheral blood; (3) > or = 2.0% myeloblasts in the bone marrow; (4) positive periodic acid schiff (PAS) stained nucleated erythrocytes; (5) myeloid differentiation index > or = 1.8; (6) typical colonal karyotypic abnormalities; (7) negative sister chromatid differentiation; (8) cluster/colony ratio of granulocyte-macrophage colony-forming units (CFU-GM) > 4.0. The following criteria were assigned: A: to meet variable one and at least two of the other seven variables and B: to meet at least four of the eight variables. All of the patients with preleukemia met either A or B and none of the patients with CAA or a-PNH did.
CONCLUSIONSPreleukemia is different from CAA or a-PNH. It has its own clinical and laboratory features, which may be useful for its prospective diagnosis.
