Nestin expression and proliferation of ependymal cells in adult rat spinal cord after injury.
- Author:
Kui LIU
1
;
Zhongcheng WANG
;
Hongyun WANG
;
Yazhuo ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Division; Ependyma; cytology; metabolism; Immunohistochemistry; Intermediate Filament Proteins; biosynthesis; Male; Nerve Tissue Proteins; Nestin; Rats; Rats, Wistar; Spinal Cord Injuries; metabolism; pathology
- From: Chinese Medical Journal 2002;115(3):339-341
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine cell proliferation and nestin expression in the ependyma of adult rat spinal cord after injury.
METHODSRat spinal cord injury models were established by aneurysm clip compression, and nestin expression and proliferation of ependymal cells at different times were shown with pathological and immuno-histochemical staining.
RESULTSEpendymal cells adjacent to the injured site demonstrated a dramatic increase in nestin expression 24 hours after compression. Proliferating cell nuclear antigen was positive, and significant proliferation was observed after 7 days. Nestin expression was down regulated as time went by.
CONCLUSIONNormally quiescent mature ependymal cells appear to revert to an embryonic state in response to spinal cord injury.
