Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats.
- Author:
Jianzhong ZHOU
1
;
Han LEI
;
Yunzhen CHEN
;
Faqi LI
;
Changsheng MA
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Flavanones; Flavonoids; pharmacology; Hypertension; physiopathology; Male; Protective Agents; pharmacology; Protein Kinase C; antagonists & inhibitors; Random Allocation; Rats; Rats, Inbred SHR; Ventricular Remodeling; drug effects
- From: Chinese Medical Journal 2002;115(3):375-377
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo observe reversal of ventricular remodeling by the protein kinase C inhibitor Scutellarein in spontaneously hypertensive rats (SHRs).
METHODSTwelve SHRs were randomly divided into two groups. Scutellarein and saline (10 mg x kg(-1) x d(-1)) were given by intraperitoneal injection to two groups of rats separately. Systolic blood pressure (SBP) and ventricular weight index (LVW/BW, RVW/BW) were measured. A polarization microscope and an image analyzer system (IAS) were used to observe changes in cardiovascular structure and to count the content of cardiac muscle interstitial collagen.
RESULTSThe pathologic changes in the left ventricle in the Scutellarein group rats (SHR(D)) improved to varying degrees, including hypertrophy of the cardiac muscle and collagen volume fraction.
CONCLUSIONScutellarein can reverse ventricular remodeling, improve myocardial stiffness and protect heart cardiac muscle.
