Study on the association between polymorphisms in angiotensinogen gene and deep venous thrombosis.

Hua Zhang; Ying HE; Jian-hua Lian; Hua QI; Ran Jing; Hong Zheng

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Study on the association between polymorphisms in angiotensinogen gene and deep venous thrombosis.

Author: Hua ZHANG ¹ ; Ying HE ; Jian-hua LIAN ; Hua QI ; Ran JING ; Hong ZHENG
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1. Department of Cell Biology and Medical Genetics, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, 450052 People's Republic of China.
Publication Type:Journal Article
MeSH: Adult; Angiotensinogen; genetics; Female; Genetic Predisposition to Disease; genetics; Genotype; Haplotypes; genetics; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length; Venous Thrombosis; genetics
From: Chinese Journal of Medical Genetics 2008;25(3):300-303
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the association of polymorphism of angiotensinogen (AGT) -6G/A, -20A/C and T174M with the development of deep venous thrombosis.
METHODSOne hundred and three patients with deep venous thrombosis (DVT group) and 250 healthy subjects (control group) were recruited in the study. The polymorphisms of angiotensinogen -6G/A, -20A/C and T174M were detected by PCR-RFLP.
RESULTSThe prevalence of GA genotype of -6G/A in the DVT group was significantly higher than that in the control group(P< 0.05) and the prevalence of -20A/-6A/174T haplotype in the DVT group was lower than that in the control group(P< 0.05). There were no significant differences in the prevalence of -20A/C and T174M polymorphism.
CONCLUSIONThe GA genotypes of -6G/A may increase the development of DVT and the -20A/-6G/174T haplotype may be a risk factor of DVT. However, the -20A/-6A/174T haplotype may be a protective factor of DVT.