Relationship between the gene mutations of mannose binding protein and the progression of hepatitis B infection.
- Author:
Fu-yi TONG
1
;
Jian-he GAN
;
Qin LU
;
Wen-gui CAO
;
Xiu-juan SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Codon; genetics; Female; Hepatitis B; genetics; Humans; Male; Mannose-Binding Lectin; genetics; Middle Aged; Mutation; genetics; Polymerase Chain Reaction; Young Adult
- From: Chinese Journal of Medical Genetics 2008;25(3):331-333
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the gene mutations of mannose binding protein(MBP) and the progression of hepatitis B.
METHODSThe MBP gene mutations in 52 patients with chronic hepatitis B and 62 patients with severe hepatitis B and 64 HBsAg-negative healthy controls were investigated. The mutations in MBP gene were analyzed by polymerase chain reaction (PCR) and direct DNA sequencing.
RESULTSA mutation of MBP gene codon 54 was found. The mutation frequency in the group of severe hepatitis B (35.5%, 22/62) was higher than those in the chronic hepatitis B group (15.4%, 8/52) and the HBsAg-negative healthy controls(14.1%, 9/64), respectively, and their difference was significant (chi-square was 7.79, P< 0.01; chi-square was 5.89,lzP<0.05). The difference between the chronic hepatitis B group and the HBsAg-negative healthy control group was not significant (P > 0.05).
CONCLUSIONThere is only mutation in codon 54 of the MBP gene in patients with hepatitis B infection in the area analyzed. Codon 54 mutation of MBP gene is not related to the persistence of hepatitis B, but it was associated with the progression of hepatitis B infection.
