Linkage analysis of one family with autosomal dominant high myopia.
- Author:
Jin-xia CHANG
1
;
Ding-ding ZHANG
;
Yin LIN
;
Bing LIU
;
Fang LU
;
Xin TANG
;
Yang YANG
;
Bin CHEN
;
Chong-jie ZHANG
;
Zheng-lin YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Female; Genetic Linkage; Humans; Lod Score; Male; Microsatellite Repeats; genetics; Middle Aged; Myopia; genetics; Pedigree; Polymorphism, Single Nucleotide; Refraction, Ocular; physiology; Young Adult
- From: Chinese Journal of Medical Genetics 2008;25(4):424-426
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo map the high myopia gene in a Chinese family with autosomal dominant high myopia.
METHODSA family with autosomal dominant high myopia in three generations was collected. Eighteen short-tandem-repeat markers on previously reported loci linked to high myopia were chosen for genotyping and two-point linkage analysis was carried out.
RESULTSThe spherical equivalent of affected individuals ranges from -6.00D to -20.00D and the genetic pattern is autosomal dominant. The LOD score was less than -1 in all 18 microsatellite markers, indicating that there was no linkage between these markers and the high myopia related genes in this family.
CONCLUSIONA novel myopia locus for high-grade myopia may exist in the kindred. Genome-wide scan will be needed to determine this novel locus.
