Association of interleukin-18 gene polymorphism with genetic susceptibility to systematic lupus erythematosus in Guangxi Zhuang population.
- Author:
Yan LAN
1
;
Ye-sheng WEI
;
Xiu-sheng TANG
;
Jun QIN
;
Jie WU
;
Ji-min QIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Interleukin-18; genetics; Lupus Erythematosus, Systemic; genetics; Male; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Groups; Risk Factors
- From: Chinese Journal of Medical Genetics 2008;25(4):434-437
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of the single nucleotide polymorphisms of interleukin-18 (IL-18) gene with the susceptibility to systematic lupus erythematosus (SLE) in a Chinese Zhuang population.
METHODSTwo single nucleotide polymorphisms of the IL-18 gene promoter were analyzed, namely -137G/C and -607C/A, in 115 patients with SLE and 160 age and sex-matched controls in a Chinese Zhuang population, using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy and DNA sequencing.
RESULTSThe IL-18 gene -607C/A polymorphism was significantly different between the SLE and control group (P < 0.05). The relative risk of SLE for -607C allele carrier was 1.619 times of the -607A allele carriers (OR=1.619, 95%CI: 1.150-2.281). Consistent with the results of the genotyping analyses, IL-18 -137G/-607C allele frequencies in patients with SLE was significant higher than that in controls (P < 0.05). The -137G/-607C allele was associated with a significantly increased risk of SLE (OR=1.484, 95%CI: 1.056-2.087). However, there was no difference of the distributions of the -137G/C polymorphism of the IL-18 gene between the SLE and control groups.
CONCLUSIONIL-18 gene -607C/A polymorphism was associated with SLE, the -607C allele may be a risk factor for SLE.
