Treatment of a Patient with Kaposi's Sarcoma Arising during Hemodialysis with the Multikinase Inhibitor Pazopanib.
10.3904/kjm.2015.89.1.113
- Author:
You Jin CHUN
1
;
Ah Ran CHOI
;
Seo Yeon YANG
;
Hyo Eun KIM
;
Jang Ho CHO
;
Jae Yun LIM
;
Jae Yong CHO
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. chojy@yuhs.ac
- Publication Type:Case Report
- Keywords:
Pazopanib;
Sarcoma, Kaposi;
Renal dialysis
- MeSH:
Biopsy;
Glomerulonephritis;
Herpesvirus 8, Human;
Humans;
Kidney Failure, Chronic;
Knee;
Protein-Tyrosine Kinases;
Renal Dialysis*;
Sarcoma;
Sarcoma, Kaposi*;
Skin
- From:Korean Journal of Medicine
2015;89(1):113-116
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Kaposi's sarcoma (KS) is an unusual multifocal neoplastic angioproliferative disorder. We herein report a case of classic KS that occurred in a patient receiving hemodialysis for 7 years. The patient had a history of chronic renal failure due to glomerulonephritis for 20 years. Multiple reddened violaceous patches, plaques, and nodules were found on the right knee. Biopsy revealed positivity for human herpesvirus 8 (KS-associated herpesvirus) consistent with KS. Pazopanib, a multitarget tyrosine kinase inhibitor, is an effective agent for treatment of advanced soft tissue sarcoma. The patient received pazopanib for 6 months investigate its effects on KS. The skin lesions and painful symptoms showed improvement. Further studies are required to determine the mechanism underlying the anticancer action of pazopanib and the pathogenesis of KS.
