DC-SIGNR polymorphisms and its association with HIV-1 infection.
- Author:
Hui WANG
1
;
Chunhui WANG
;
Tiejian FENG
;
Hua ZHOU
;
Lixiong LI
;
Feng WANG
;
Guanglu ZHAO
;
Tuofu ZHU
;
Boping ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Cell Adhesion Molecules; genetics; Cohort Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; HIV Infections; genetics; transmission; virology; HIV-1; Humans; Lectins, C-Type; genetics; Male; Polymorphism, Genetic; Receptors, Cell Surface; genetics
- From: Chinese Journal of Medical Genetics 2008;25(5):542-545
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association of the polymorphism of homologue of dendritic cell-specific intercellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN related, DC-SIGNR) gene with the susceptibility to HIV-1 infection.
METHODSThe distribution of the DC-SIGNR variants in the tandem repeat region and their association with HIV-1 infection in a cohort composed of 345 HIV-1 seropositive and 468 high-risk HIV-1 seronegative individuals was examined.
RESULTSThere are 14 genotypes and 5 alleles in the DC-SIGNR repeat regions in the cohort. Although the most common DC-SIGNR allele among Chinese Han population and the Caucasian population is 7, it was found in a higher frequency in the Chinese than in Caucasians (67.1% vs.46.0%, P<0.01). HIV-1 seropositive individuals had a lower frequency of the genotype 7/7 than the high-risk seronegative individuals (38.55% vs. 48.29%, P=0.0057), but a higher frequency of genotype 9/5 (4.35% vs. 1.07%, P=0.0029).
CONCLUSIONThese results suggest that the tandem-repeat polymorphisms of the DC-SIGNR gene in the Chinese Han population exhibit unique genetic characteristics previously unrecognized in the Caucasian population. Genotype 9/5 seems to be a risk factor for HIV-1 infection in the Chinese population.
