Association of the DJ-1 gene polymorphism with sporadic Parkinson's disease in Sichuan province of China.
- Author:
Wenjun CHEN
1
;
Rong PENG
;
Tao LI
;
Yan WU
;
Jinhong ZHANG
;
Yincheng WANG
;
Guanggu YUAN
;
Yinru GOU
;
Quying JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Age of Onset; Aged; Aged, 80 and over; Asian Continental Ancestry Group; genetics; Base Sequence; Case-Control Studies; China; Female; Gene Frequency; Genotype; Humans; Intracellular Signaling Peptides and Proteins; genetics; Male; Middle Aged; Oncogene Proteins; genetics; Parkinson Disease; genetics; pathology; Polymorphism, Genetic; Protein Deglycase DJ-1
- From: Chinese Journal of Medical Genetics 2008;25(5):566-569
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the frequencies of three polymorphisms in DJ-1 (g.168-185del; SNP405, refSNP ID:rs3766606 and 293 G/A) and their association with sporadic Parkinson's disease.
METHODSAn association study was performed to determine the genotype of each subject using polymerase chain reaction, restriction fragment length polymorphism and sequence analysis in 192 patients with sporadic Parkinson's disease and 198 healthy controls.
RESULTSIn the g.168-185del locus, the Ins/Ins genotype was common and the frequency of Del allele was very low (0.38%). The SNP of 293G/A was not detected in both groups. In the SNP405 G/T site, the GT genotype frequency was significantly higher in patients with age of onset before 40 years than in controls (18.75% vs 5.54%, P=0.004, OR=6.30 95%CI:1.96-20.18).
CONCLUSIONThe results suggest that the frequencies of the g.168-185del and 293G/A polymorphisms might be different between Chinese and European. The SNP405 GT genotype might be a risk factor for sporadic Parkinson's disease with early age of onset in Sichuan Han population.
