Association of single nucleotide polymorphism rs599839 on chromosome 1p13.3 with premature coronary heart disease in a Chinese Han population.
- Author:
Hao HUANG
1
;
Lingai PAN
;
Li ZHANG
;
Yucheng CHEN
;
Zhi ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; genetics; Case-Control Studies; Chromosomes, Human, Pair 1; genetics; Coronary Disease; blood; genetics; pathology; Ethnic Groups; genetics; Female; Gene Frequency; Genotype; Humans; Lipids; blood; Male; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2008;25(6):686-689
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of single nucleotide polymorphism (SNP) rs599839 on chromosome 1p13.3 with premature coronary heart disease.
METHODSA case-control association study of 303 unrelated premature coronary heart disease patients and 312 normal controls from a Chinese Han population was performed. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism for SNP rs599839 on Chromosome 1p13.3.
RESULTSThe frequencies of the G allele were 5.0% and 9.1% in the premature coronary heart disease group and control group respectively (P= 0.004). The presence of the G allele was associated with significantly lower concentration of the low density lipoprotein-cholesterol (LDL-C) in both groups.
CONCLUSIONThe present findings suggest that the genetic polymorphism in rs599839 may be associated with the development of premature coronary heart disease in Chinese Han population, and the polymorphism may have some influence on serum LDL-C level in this population.
