Association of polymorphism of the prostacyclin synthase gene with myocardial infarction in Uigur population of Xinjiang.
- Author:
Xiang XIE
1
;
Yitong MA
;
Zhenyan FU
;
Yining YANG
;
Yinghong WANG
;
Bangdang CHEN
;
Fen LIU
Author Information
- Publication Type:Journal Article
- MeSH: 6-Ketoprostaglandin F1 alpha; blood; Asian Continental Ancestry Group; genetics; Base Sequence; Case-Control Studies; Cytochrome P-450 Enzyme System; genetics; Ethnic Groups; genetics; Exons; genetics; Female; Gene Frequency; Genotype; Humans; Intramolecular Oxidoreductases; genetics; Logistic Models; Male; Middle Aged; Myocardial Infarction; blood; genetics; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2008;25(6):708-711
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the polymorphism of the prostacyclin synthase gene and Uigur patients with myocardial infarction in Xinjiang.
METHODSThree hundred and ten patients with myocardial infarction (MI) and 306 healthy control subjects were detected by polymerase chain reaction and restriction fragment length polymorphism. The serum 6-keto-PGF(1alpha ) was detected with radioimmunoassay kit in all subjects.
RESULTSThe genotype distributions of the control group and MI group were in the Hardy-Weinberg equilibrium(chi (2)= 0.442, 1.867, P> 0.05). The frequencies of CC, CA and AA were 0.70, 0.26 and 0.03 in the MI group and 0.62, 0.32 and 0.06 in the controls. There was significant difference in frequencies of CC genotype and C allele but no difference in frequencies of CA and AA genotypes between the controls and the MI cases. There was significant difference in serum 6-keto-PGF(1alpha ) level between the MI group and control group (P< 0.05), as well as among the three genotypes (P< 0.05). In the cases with CC genotype the serum 6-keto-PGF(1alpha ) level was lower than that of others (P< 0.05).
CONCLUSIONThe CC genotype and C allele of the prostacyclin synthase gene might be a risk factor of MI in Uigur population in Xinjiang, which may lead to the decreased serum 6-keto-PGF(1alpha ) level.
