Association of serotonin transporter gene linked polymorphic region polymorphism with early onset myocardial infarction and platelet membrane glycoprotein I b.
- VernacularTitle:5-羟色胺转运体基因启动子连锁多态区多态性与早发心肌梗死及血小板膜糖蛋白Ⅰb的关系
- Author:
Da-sheng XIA
1
;
Qian-yu GUO
;
Yan-qiang LIU
;
Chao LI
;
Feng ZHANG
;
Min-xin WEI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Age of Onset; Alleles; Asian Continental Ancestry Group; genetics; Case-Control Studies; Ethnic Groups; genetics; Female; Gene Frequency; Homozygote; Humans; INDEL Mutation; Logistic Models; Male; Middle Aged; Myocardial Infarction; genetics; metabolism; pathology; Platelet Glycoprotein GPIb-IX Complex; metabolism; Polymorphism, Genetic; Serotonin Plasma Membrane Transport Proteins; genetics
- From: Chinese Journal of Medical Genetics 2009;26(1):31-34
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of serotonin transporter gene linked polymorphic region (5-HTTLPR) insertion/deletion polymorphism with early onset myocardial infarction(MI) and platelet membrane glycoprotein I b(GP I b) in Northern Han population of China.
METHODSA total of 150 patients with early onset MI and 150 age- and sex-matched controls with negative coronary arteriography were genotyped for the 5-HTTLPR polymorphism by using a polymerase chain reaction-based technique. The percentage of positive platelet membrane GP I b and the average fluorescence intensity were quantified by flow cytometry.
RESULTSThe genotype frequencies of LL, LS and SS in the 5-HTTLPR were 32%, 47% and 21% in the MI patients, 17%, 43% and 39% in the controls respectively(P<0.01). The L allele frequency in the MI patients was significantly higher than that of the control group (56% vs 39%, P<0.01). The percentage of positive platelet membrane GP I b and the fluorescence intensity in subjects with LL homozygote were markedly lower than that of LS and SS genotypes in the MI and control groups (all P<0.01). Multivariate logistic regression analysis showed that the 5-HTTLPR LL genotype was independently related to the occurrence of early onset MI(OR was 1.961, P was 0.037).
CONCLUSIONThe LL genotype of the 5-HTTLPR might be associated with the susceptibility to developing early MI in Northern Han population of China. The platelet activation is increased in individuals of LL genotype.