STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine.
- Author:
Li-ying LIU
1
;
Chen HUANG
;
Zong-fang LI
;
Ai-ying WANG
;
Xiao-yan HU
;
Lei NI
;
Lin YU
;
Tu-sheng SONG
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; drug effects; Cell Proliferation; Hep G2 Cells; Humans; Phosphatidylethanolamines; pharmacology; STAT1 Transcription Factor; metabolism; STAT2 Transcription Factor; metabolism
- From: Journal of Southern Medical University 2011;31(2):256-258
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine (PE) in human hepatoma HepG2 cells.
METHODSThe growth of HepG2 cells exposed to 0.125, 0.25, 0.5 and 1.0 mmol/L PE was assessed by MTT assay, and the expressions of STAT1 and STAT2 were analyzed using immunocytochemical assay.
RESULTSPE inhibited the growth of HepG2 cells in a dose-dependent manner and increased the expression of STAT1 and STAT2 in comparison with those in the control group. AG490, an inhibitor of JAKs, partially reversed PE-induced growth inhibition of HepG2 cells.
CONCLUSIONSTAT1 and STAT2 are involved in the growth inhibition of human hepatoma HepG2 cells induced by PE.
