Correlation of CerbB-2 to Ki-67 and P53 expressions in hormone-independent breast cancer.
- Author:
Qi FANG
1
;
Xue-fen WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Breast Neoplasms; metabolism; Female; Humans; Ki-67 Antigen; genetics; metabolism; Middle Aged; Prognosis; Receptor, ErbB-2; genetics; metabolism; Receptors, Estrogen; metabolism; Receptors, Progesterone; metabolism; Tumor Suppressor Protein p53; genetics; metabolism
- From: Journal of Southern Medical University 2011;31(2):380-382
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relation of CerbB-2 with Ki-67 and P53 expressions in hormone-independent breast cancer.
METHODSA total of 180 patients with breast cancer were examined for the positivity to estrogen receptor (ER) and progesterone receptor (PR), and subsequently divided into hormone-dependent group (positive for both ER and PR) and hormone-independent group (negative for both). CerbB-2, Ki-67 and P53 expressions were detected in these patients using an improved Envision immunohistochemical staining with the corresponding antibodies. Twenty-nine patients without definite immunohistochemical results of C-erbB-2 were excluded from further analysis. The 51 hormone-independent and 100 hormone-dependent cases were analyzed for the correlation of CerbB-2 to Ki-67 and P53 expressions.
RESULTSIn hormone-independent cases negative for CerbB-2, Ki-67 and P53 expressions were significantly higher than that in hormone-dependent CerbB-2-negative cases (P<0.05), but in CerbB-2-positive cases, their expressions showed no significant differences (P>0.05) with respect to hormonal dependence.
CONCLUSIONIn hormone-independent CerbB-2-negative cases, the tumor cells show a higher proliferative activity and P53 expression than those in hormone-dependent cases, which can be an important reason for the high malignancy and poor prognosis of hormone-independent breast cancer negative for CerbB-2.
