Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients.
- Author:
Min WANG
1
;
Fang GAO
;
Yao-ming XUE
;
Ya-juan HAN
;
Xia-jun FU
;
Fei-ying HE
Author Information
- Publication Type:Journal Article
- MeSH: Diabetes Mellitus, Type 2; drug therapy; Drug Therapy, Combination; Female; Humans; Male; Metformin; therapeutic use; Sulfonylurea Compounds; therapeutic use; Treatment Outcome
- From: Journal of Southern Medical University 2011;31(3):564-566
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of short-term intensive therapy on blood glucose control, BETA-cell function, and blood lipid levels in newly diagnosed type 2 diabetic patients.
METHODSOut-patients with newly diagnosed type 2 diabetic patients were enrolled for intensive treatment with sulfonylureas and metformin for 12 weeks, and the therapeutic effect was evaluated.
RESULTSAfter the intensive treatment, FPG, 2 hPG, and HbA1c decreased significantly (P<0.01); HOMA-IR decreased and HOMA-B increased significantly (P<0.01), and TG, CHOL, LDL decreased significantly (P<0.01) after the treatment.
CONCLUSIONShort-term intensive treatment with glimepiride combined with metformin is safe and effective in newly diagnosed type 2 diabetic patients with HbA1c>9%.
