p53 Expression in a Malignant Mesothelioma Patient during Seven-Year Follow-up.
10.4046/trd.2014.76.6.284
- Author:
So My KOO
1
;
Soo Taek UH
;
Dong Won KIM
;
Ki Up KIM
;
Yang Ki KIM
Author Information
1. Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. uhs@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Mesothelioma;
Tumor Suppressor Protein p53;
Pleura
- MeSH:
Aged;
Biology;
Chest Pain;
Diagnosis;
Follow-Up Studies*;
Genes, p53;
Humans;
Hyperplasia;
Male;
Mesothelioma*;
Pleura;
Pleural Effusion;
Thorax;
Tomography, X-Ray Computed;
Tumor Suppressor Protein p53
- From:Tuberculosis and Respiratory Diseases
2014;76(6):284-288
- CountryRepublic of Korea
- Language:English
-
Abstract:
Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies. We believed that there are changes in the p53 expression with transformation from reactive hyperplasia to MM. A 65-year-old male was admitted the hospital because of left pleuritic chest pains in 2004. Chest computed tomography (CT) results showed left pleural effusions with loculation and pleural thickening. Pathologic findings revealed reactive mesothelial hyperplasia. In 2008, the patient again felt left pleuritic chest pains. Chest CT showed progressive thickening of the left pleura. Pathologic diagnosis was atypical mesothelial hyperplasia. In 2011, chest CT showed progressive thickening of his left pleura. He was diagnosed with well-differentiated papillary mesothelioma. Serial change was analyzed by immunohistochemical staining for p53 of pleural tissues. There were no remarkable changes in p53 expressions during the transformation to MM.
