Preparation and in vitro release of ginkgo biloba extract sustained-release tablets.
- Author:
Qihua CUI
1
;
Yunfeng ZHU
;
Jinghao CUI
Author Information
- Publication Type:Journal Article
- MeSH: Delayed-Action Preparations; chemistry; Drug Compounding; methods; Drug Stability; Ginkgo biloba; chemistry; Plant Extracts; chemistry; Tablets; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(15):1910-1913
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare ginkgo biloba extract (GBE) sustained-release tablets and observe its in vitro release profile.
METHODGBE sustained-release tablets were prepared by direct compression method using sodium carboxymethylcellulose (CMC-Na) and hydroxypropyl methylcellulose HPMC) as matrix excipients. Based on the result of single-factor selecting experiment, the formulations and preparation process were optimized through orthogonal design, and release difference of tablets was evaluated with similarity factor (f2).
RESULTThe ratio of HPMC and CMC-Na, the viscosity of HPMC and the different types of the diluents had pronounced effect on the release of GBE sustained release tablets, although the hardness and weight difference of tablets did not show notable influences.
CONCLUSIONGBE sustained-release tablets that prepared by using the mixture of HPMC and CMC-Na display constant release profile in 12 h.
