Cycloartane triterpenoid of Cimicifuga foetida.
- Author:
Chun DAN
1
;
Jian LIANG
;
Yan ZHOU
;
Lisheng DING
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cells, Cultured; Cimicifuga; chemistry; Drugs, Chinese Herbal; chemistry; pharmacology; Mice; Osteoclasts; drug effects; Triterpenes; chemistry; pharmacology
- From: China Journal of Chinese Materia Medica 2009;34(15):1930-1934
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study cycloartane triterpenoid of Cimicifuga foetida and their osteoclast inhibition activity.
METHODThe compounds were isolated and purified by normal and reversed phase column chromatographic methods. Structures were identified by spectroscopic analyses. Their osteoclast inhibition activity was then studied.
RESULTThirteen cycloartane triterpenoids were isolated from the rhizomes of C. foetida and were characterized as 25-O-acetyl-cimigenol (1), cimigenol (2), cimicidanol (3), 26-deoxyactein (4), asiaticoside A (5), 23-epi-26-deoxyactein (6), actein (7), 12beta-hydroxycimigenol (8), cimiside E (9), (23R, 24S) 25-O-acetyl-cimigenol-3-O-beta-D-xylopyranoside (10), (23R, 24S) cimigenol-3-O-beta-D-xylopyranoside (11), cimicifugoside H-1 (12) and cimicifugoside H-2 (13).
CONCLUSIONCompound 5 was isolated from this genus for the first time, compound 7 was isolated firstly from the plant and compound 2, 7, 10 and 11 exhibit osteoclast inhibition activity.
