Diterpenoid alkaloids from roots of Aconitum recemulosum and their inhibitory effects on PAF-induced platelet aggregation.
- Author:
Yonghui GE
1
;
Shuzhen MU
;
Jianxin ZHANG
;
Ye WANG
;
Qianyun SUN
;
Xiaojiang HAO
Author Information
- Publication Type:Journal Article
- MeSH: Aconitum; chemistry; Alkaloids; chemistry; isolation & purification; pharmacology; Coagulants; pharmacology; Diterpenes; chemistry; isolation & purification; pharmacology; Humans; Plant Extracts; chemistry; isolation & purification; pharmacology; Plant Roots; chemistry; Platelet Aggregation; drug effects
- From: China Journal of Chinese Materia Medica 2009;34(15):1935-1937
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study diterpenoid alkaloids from the roots of Aconitum recemulosum, and their inhibitory effects on PAF-induced platelet aggregation.
METHODThe root of A. recemulosum was extracted with 95% EtOH. The total alkaloids extracted were isolated and purified by several kinds of column chromatography over silica gel, RP-18, and Sephadex LH-20, and identified based on spectral analysis. And the inhibitory effects of isolated compounds on PAF-induced platelet aggregation were detected.
RESULTFive alkaloids were isolated and identified as sachaconitine (1), 14-acetylsachaconitine (2), hemsleyanine C (3), circinasine A (4), and talatisamine (5). The results showed compounds 1 and 2 have moderate inhibition effect on PAF.
CONCLUSIONCompounds 1-5 were firstly isolated from this plant. Furthermore, compounds 1 and 2 possessed moderate inhibitory effects on PAF-induced platelet aggregation.
