Effect of Santalum album on tissue distribution of danshensu in rabbits by HPLC.
- Author:
Qian ZHANG
1
;
Yimei TANG
;
Rui WANG
;
Shixiang WANG
;
Minfeng FANG
;
Yajun ZHANG
;
Xiaohui ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; drug effects; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; administration & dosage; analysis; pharmacokinetics; Heart; drug effects; Kidney; drug effects; Lactates; administration & dosage; analysis; pharmacokinetics; Liver; drug effects; Rabbits; Santalum; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(15):1968-1970
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the influence of Shi herb (Santalum album, SA) to the tissue distribution of danshensu (DSS) which is the main hydrosoluble component of Jun herb (Salvia miltiorrhiza, SM) in rabbits by HPLC.
METHODRabbits were oral administrated decoction of SM and SM-SA, respectively. Perchloric acid (10%) was used to precipitate the tissue samples of rabbits heart, brain, liver, kidney, acetic ether was used to extracte supernatant, and the internal standard was p-hydroxybenzoic acid. The content of DSS of SM in tissues was detected.
RESULTThe content of DSS reached the highest point close to 50 min in the mentioned tissues. Before and after co-administration, the sequences of average concentration of DSS in tissues were C(kidney) > C(heart) > C(brain) > C(liver) and C(kidney) > C(liver) > C(brain) > C(heart) respectively. Compared with SM administrated singly, the content of DSS in every tissues of co-administration was higher.
CONCLUSIONIn Danshenyin Formulae, SA can increase concentration of DSS in target tissues significantly, and therefore therapeutic effect of SM for cardiovascular disease is raised.
