Primary studies of toxicity-reducing and efficacy-maintaining action of fungal fermentative products in Tripterygium wilfordii by a novel bi-directional solidstate fungal fermentation.

Author: Yi ZHUANG ¹ ; Xiaomei XIE
Author Information

1. Jiang Xi University of Traditional Chinese Medicine, Key Laboratory of Modern Preparation of Traditonal Chinese Medicine, Mycomedicine Research Center, Nanchang 330004, China.
Publication Type:Journal Article
MeSH: Animals; Culture Techniques; Drugs, Chinese Herbal; chemistry; metabolism; toxicity; Female; Fermentation; Fungi; metabolism; Male; Mice; Random Allocation; Tripterygium; chemistry
From: China Journal of Chinese Materia Medica 2009;34(16):2083-2087
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo get the detoxification and retentive-acting (keep the effect of immunosuppression) fungal substance of Tripterygium wilfordii Hook.
METHODThe medicinal fungal new type bi-directional solid fermentation engineering was adopted. T. wilfordii was used as medicinal substance and diverse medicinal fungus were used as fermentative strains. Fermented under certain conditions, all kinds of fungal substance that we got were dealt with preliminary research on chemistry and toxicity.
RESULTTwo kinds of fermentative fungus which had effects of detoxification and keeping immunosuppression were selected and appropriate zymotechnique was found.
CONCLUSIONMedicinal fungal new type bi-directional solid fermentation technique can be applied in the area of the detox and retentive-acting effect of T. wilfordii.