Study on sugarcane alkane alcohol to quail hyperlipidemia and atherosclerosis model.
- Author:
Zhongfeng SHI
1
;
Qixin YAN
;
Jinhua ZHAO
;
Guanghui YAO
Author Information
- Publication Type:Journal Article
- MeSH: Alkanes; chemistry; therapeutic use; Animals; Atherosclerosis; drug therapy; Cholesterol; blood; Disease Models, Animal; Ethanol; chemistry; therapeutic use; Hyperlipidemias; drug therapy; Male; Plant Extracts; chemistry; therapeutic use; Quail; Random Allocation; Saccharum; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(16):2092-2096
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study on pharmacologic actions on quail hyperlipidemia and atherosclerosis model.
METHODTo duplicate quail hyperlipidemia model by ectogenesis cholesterol and high fat forage, induce to atherosclerosis model, observe influence of sugarcane alkane alcohol to model animals' blood fat level, formation of atherosclerosis plaque, pathological changes of coronary vessels and vascular intimal.
RESULTTC, TG, LDL-C level in blood serum of quail hyperlipidemia markedly decreased after administered sugarcane alkane alcohol by dose of 30, 15, 7.5 mg x kg(-1), proliferation of aorta and brachiocephalic artery tunica intima foam cells was suppressed.
CONCLUSIONSugarcane alkane alcohol has satisfactory pharmacologic actions on hyperlipidemia and atherosclerosis animal model by regulating blood fat.
