Preparation and transdermal diffusion of flexible nanoliposomes of ginkgolide B.
- Author:
Ting LIU
1
;
Xiaolong ZHEN
;
Hao CHENG
;
Weize LI
;
Baohua HAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Ginkgolides; chemistry; pharmacokinetics; Lactones; chemistry; pharmacokinetics; Liposomes; chemistry; pharmacokinetics; Male; Mice; Nanoparticles; chemistry; Particle Size; Permeability; Random Allocation; Skin Absorption
- From: China Journal of Chinese Materia Medica 2009;34(17):2181-2184
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare flexible nanoliposomes of Ginkgolid B (GB) and study the transdermal diffusion law.
METHODFlexible nanoliposomes of GB were prepared by film dispersion method, and the shape and particle size of nanoliposomes were analyzed. GB permeation tests in vitro through the skin of rats were performed in modified Franz diffusion cell. The accumulated permeation amounts of GB alcoholic solution, flexible nanoliposomes of GB and ordinary nanoliposomes of GB were compared.
RESULTThe average encapsulation percentage, the particle size, and the Zata potential of the flexible nanoliposomes were (89.52 +/- 1.76)%, and was (208.3 +/- 25.49) nm, and was -49.2 mV, respectively. The accumulated permeation amount of flexible nanoliposomes in 8 hours was 189.97 microg x cm(-2), and its transdermal permeability in 8 hours was 23.75 microg x cm(-2) x h(-1).
CONCLUSIONThe encapsulation percentage of the flexible nanoliposomes is good,and the stability of the GB nanoliposomes is fine. Flexible nanoliposomes can significantly enhance the diffusion rate of GB through the skin of rats.
