Preparation and in vitro evaluation of brucine-loaded polylacticacid nanoparticles.
- Author:
Jihui ZHAO
1
;
Zhaolin LIU
;
Jie XU
;
Yanyan YU
;
Nianping FENG
Author Information
- Publication Type:Journal Article
- MeSH: Drug Carriers; chemistry; Drug Delivery Systems; methods; Drugs, Chinese Herbal; chemistry; Kinetics; Lactic Acid; chemistry; Nanoparticles; chemistry; Particle Size; Polyesters; Polymers; chemistry; Strychnine; analogs & derivatives; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(18):2322-2324
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare and evaluate brucine-loaded polylacticacid nanoparticles (Bru-PLA-NPs).
METHODThe Bru-PLA-NPs were prepared by solvent diffusion method. The physical, chemical properties and in vitro release behavior of the prepared Bru-PLA-NPs were evaluated, respectively.
RESULTThe mean particle size of the prepared Bru-PLA-NPs was 95 nm with polydispersity index of 0.362. The zeta potential was -15.68 mV. The mean loading and entrapment efficiency of Bru were 7% and 37%, respectively. Compared with Bru solution, an obvious sustained release behavior of Bru from Bru-PLA-NPs was observed in the in vitro release experiment.
CONCLUSIONThe Bru-PLA-NPs prepared by solvent diffusion method exhibit small particle size, high Bru-loading efficiency, and obvious sustained release in vitro
