Aporphine alkaloids from branches and leaves of Polyalthia nemoralis.
- Author:
Ziming LU
1
;
Qingjian ZHANG
;
Ruoyun CHEN
;
Dequan YU
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents, Phytogenic; chemistry; isolation & purification; pharmacology; Aporphines; chemistry; isolation & purification; pharmacology; Cell Line, Tumor; Humans; Plant Leaves; chemistry; Plant Stems; chemistry; Polyalthia; chemistry
- From: China Journal of Chinese Materia Medica 2009;34(18):2343-2345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the aporphine alkaloids in the branches and leaves of Polyalthia nemoralis.
METHODThe compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatographies. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data.
RESULTFive aporphine alkaloids were isolated and identified as: bidebiline A (1), annobraine (2), lanuginosine (3), liriodenine (4), oxostephanosine (5), respectively.
CONCLUSIONFor the first time, Compounds 2 and 5 were obtained from Polyalthia while 1, 3 and 4 isolated from this plant. The bioassays in vitro against five human tumor cell lines with MTT method showed moderate cytotoxic activities (IC50 1 mg x L(-1)) of compounds 3-5.
