Freeze-drying of oleanolic acid-loaded nanosuspensions.
- Author:
Xiao-Ling ZHAO
1
;
Hua-Bing CHEN
;
Ya-Jun CHEN
;
Xiang-Liang YANG
Author Information
- Publication Type:Journal Article
- MeSH: Cryoprotective Agents; chemistry; pharmacology; Drug Stability; Freeze Drying; methods; Microscopy, Electron, Transmission; Nanoparticles; chemistry; ultrastructure; Oleanolic Acid; chemistry; Particle Size; Solubility; drug effects; Sucrose; chemistry; pharmacology; Suspensions
- From: China Journal of Chinese Materia Medica 2007;32(18):1874-1876
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESeveral cryoprotectants were employed to study the protective effect on the freeze-drying process of the oleanolic acid-loaded nanosuspensions (OLA-LS) in order to select the optimum formulation.
METHODThe protective effect was evaluated by measuring the mean particle size of samples before and after freeze-drying process.
RESULTSucrose with the concentration of 10% was selected as the optimum cryoprotectant. The average size of excellent sample was 236.3 nm (versus 211.2 nm of fresh one), and a much higher polydispersity index of 0.242 (versus 0.180).
CONCLUSIONThe optimum lyophilized powder could be obtained with suitable type of cryoprotectant with appropriate concentration and proper freeze-drying conditions.
