Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin.
- Author:
Hua YANG
1
;
Hong YI
;
Man-Ling LI
;
Zan-Ye CAO
;
Wei-Hong FENG
Author Information
- Publication Type:Journal Article
- MeSH: Drug Compounding; methods; Emulsions; Flavonoids; analysis; chemistry; Isoflavones; analysis; chemistry; Oils; chemistry; Particle Size; Solubility; Surface-Active Agents; chemistry; Water; chemistry
- From: China Journal of Chinese Materia Medica 2007;32(19):1996-1999
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of O/W Microemulsion in enhancing solubility of baicalin and puerarin.
METHODThe Pseudo-ternary phase diagram was employed to selected the formulations of O/W microemulsion. The partical size of microemulsion, and solubility of baicalin and puerarin in water, oil phase, surfactant, microemulsion and alcohol were determined, respectively.
RESULT11 types of microemulsion formulations have the effect in enhancing the solubility of baicalin and puerarin; the solubility of Baicalin in microemulsion is higher as 5-15 times than it in water, the solubility of Puerarin in microemulsion is higher as 3 - 4 times than it in water.
CONCLUSIONMicroemulsion is good in enhancing solubility of effective compounds extracted from Chinese medical herbs.
