In vitro evaluation of self-emulsifying drug delivery system of volatile oil from rhizome of Ligusticum chuanxiong.
- Author:
Qin CAI
1
;
Long LIANG
;
Yan-Ping HUANG
;
Shi-Xiang HOU
Author Information
- Publication Type:Journal Article
- MeSH: Drug Compounding; methods; Drug Delivery Systems; Drug Stability; Emulsions; Light; Ligusticum; chemistry; Oils, Volatile; administration & dosage; chemistry; isolation & purification; Particle Size; Plants, Medicinal; chemistry; Rhizome; chemistry; Solubility; Surface-Active Agents; chemistry; Temperature; Time Factors
- From: China Journal of Chinese Materia Medica 2007;32(19):2003-2007
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the evaluation method for self-emulsifying drug delivery system of volatile oil from rhizome of Ligusticum chuanxiong (VOC SEDDS).
METHODThe self-emulsifying ability, the efficiency of self-emulsification, the properties of emulsion, the dissolution of volatile oil from Rhizome of Ligusticum Chuanxiong and the stability of the emulsion were determined.
RESULTThe optimized formulation can fully emulsify in 5 min and the particle sizes were around 102 nm. Zeta potential was about -30 mV. The O/W emulsions were stable through centrifugation with high reproducibility. In vitro dissolution test indicated that over 80% of drug dissolved in 30 min and VOC SEDDS was stable under light and high temperature in 10 d.
CONCLUSIONVOC SEDDS has strong self-emulsifying ability, fine stability and high dissolution rate in vitro.
