Nephrotoxicity of Radix Aristolochice and it's substitution material Radix Inulae in rats.
- Author:
Hong-Xiang QIAO
1
;
Yong-Ye LIU
;
Li-Mao WU
;
Lian-Da LI
Author Information
- Publication Type:Journal Article
- MeSH: Acetylglucosaminidase; urine; Animals; Aristolochia; chemistry; Blood Urea Nitrogen; Creatinine; blood; Drugs, Chinese Herbal; isolation & purification; toxicity; Female; Inula; chemistry; Kidney Tubules; drug effects; pathology; Liver; drug effects; pathology; Male; Necrosis; Plant Roots; chemistry; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Stomach; drug effects; pathology; Stomach Neoplasms; chemically induced; Urinary Bladder; drug effects; pathology; Urinary Bladder Neoplasms; chemically induced
- From: China Journal of Chinese Materia Medica 2007;32(19):2048-2051
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the toxicity of Radix Aristolochiae and Radix Inulae, and to supply the toxicity experimental data that Radix Inulae supersedes Radix Aristolochiae in clinic.
METHODA long dose of Radix Aristolochice and Radix Inulae was given intragastrically to rats for six months, then drug withdrawal for a month. The hematology and biochemical indicators were measured, and the pathologic changes of kidney, liver, stomach and urinary bladder were examined.
RESULTThe rats of Radix Aristolochice showed serious toxic responses of renal tubule atrophy and necrosis, meanwhile, the levels of BUN, Cr and NAG were increased obviously. Hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered with pathologic assaying. But the rats of Radix Inulae did not.
CONCLUSIONRadix Aristolochiae could damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity. Radix Inulae could take the place of Radix Aristolochiae to use in clinic.
