Effect of Yishen capsule on serum vascular endothelial growth factor and cell immunity in patients with chronic glomerulonephritis.
- Author:
Xi-li WU
1
;
Wan-sen SUN
;
Wang-gang ZHANG
;
Cheng-lin QIAO
;
Zhu WANG
;
Juan WANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; CD3 Complex; blood; CD4 Antigens; blood; CD4-CD8 Ratio; Capsules; Child; Chronic Disease; Drug Combinations; Drugs, Chinese Herbal; administration & dosage; isolation & purification; therapeutic use; Female; Glomerulonephritis; blood; drug therapy; immunology; Humans; Male; Middle Aged; Phytotherapy; Plants, Medicinal; chemistry; T-Lymphocyte Subsets; drug effects; immunology; Treatment Outcome; Vascular Endothelial Growth Factor A; blood; Young Adult
- From: China Journal of Chinese Materia Medica 2007;32(22):2416-2418
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of Yishen capsule on the serum vascular endothelial growth factor (VEGF), the cell immunity and the theraphic.
METHODSerum VEGF and T cell subsets were studied in 30 normal subjects and 83 patients before and after treatment.
RESULTCompare with normal subjects, CD3, CD4, CD4/CD8 were decreased, CD8 and serum VEGF were increased obviously (P <0. 05 or P <0. 01). After three months treatment with YiShen capsule, CD4/CD8 was increased, CD8 and serum VEGF were decreased significantly (P <0.05 or P <0.01).
CONCLUSIONYishen capsule can reduce the proteinuria, increase the function of immunity and improve the clinical symptom of patients with chronic glomerulonephritis, achieved the effects of allevating chronic glomerular sclerosis ultimately.
