Preparation of liposomes containing extracts of Tripterygium wilfordii and evaluation of its stability.
- Author:
Hong-Ru LI
1
;
Shu-Fen LI
;
Hong-Quan DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemistry; Cholesterol; chemistry; Drug Carriers; chemistry; Drug Compounding; methods; Drug Stability; Drugs, Chinese Herbal; chemistry; isolation & purification; Hydrogen-Ion Concentration; Liposomes; chemistry; Particle Size; Temperature; Time Factors; Tripterygium; chemistry; Triterpenes; chemistry
- From: China Journal of Chinese Materia Medica 2007;32(20):2128-2131
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe liposomes containing extracts of Tripterygium wilfordii were prepared and the possibility of entrapment of complex chemicals by liposomes were studied.
METHODThe liposomes containing extracts of T. wilfordii were prepared by thin-film dispersion method, the effect of process parameters and composition of materials on the entrapment efficiency of the main components were studied. The stability of the liposomes dispersion was also evaluated.
RESULTThe liposomes made by thin-film dispersion method were mostly small unilamellar vesicles and their particle size was 30 nm to approximately 50 nm. The optimum entrapment efficiency of tripterine and the total alkaloids were respectively 98.10% and 88.63% but the liposomes dispersion was unstable when kept at 4 degrees C.
CONCLUSIONThe complex chemicals can be entrapped by the liposomes, but its stability need to be improved furtherly.
