Studies on preparation of sinomenine hydrochloride-loaded bovine serum albumin microspheres.
- Author:
Ling-Yan ZOU
1
;
Jian-Fang FENG
;
Man-Cang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Delayed-Action Preparations; chemistry; Drug Carriers; Drug Compounding; methods; Microspheres; Morphinans; chemistry; Particle Size; Plants, Medicinal; chemistry; Serum Albumin, Bovine; chemistry; Sinomenium; chemistry
- From: China Journal of Chinese Materia Medica 2007;32(20):2131-2134
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare Sinomenine hydrochloride-loaded bovine serum albumin microspheres (SM-BSA-MS).
METHODSM-BSA-MS was prepared by spray drying technique. The morphology, drug-loading and release in vitro of SM-BSA-MS was studied.
RESULTThe diameters of SM-BSA-MS were in the range of 1-3 m. The drug loading of microspheres, formulated with different drug/albumin ratios as 1, 2, 1:1, 2:1, were 31.6%, 47.7% and 67.9% , respectively. And the drug entrapment efficiencies of different drug/albumin ratios were higher than 94%. The results of in vitro release experiments showed that the drug loaded microspheres have the properties of sustained-release compared with the Sinomenine hydrochloride injection. Different release characteristics could be obtained by adjusting the prescription composition and the thermal denaturation condition.
CONCLUSIONSpray drying technique is a simple and feasible method for preparing SM-BSA-MS. The drug loaded microspheres had high drug-loading and sustained-release effect.
