Studies on hydrolysis of aconitine.
- Author:
Qin-An HUANG
1
;
Yu-Mei ZHANG
;
Yi HE
;
Jing LU
;
Rui-Chao LIN
Author Information
- Publication Type:Journal Article
- MeSH: Aconitine; analogs & derivatives; chemistry; isolation & purification; Chromatography, High Pressure Liquid; methods; Hydrolysis; Spectrometry, Mass, Electrospray Ionization; Water; chemistry
- From: China Journal of Chinese Materia Medica 2007;32(20):2143-2145
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo find out hydrolysis regularity of aconitine.
METHODAconitine was air-tighted and hydrolyzed in water for 8, 12, 16, 20, 24 h. The hydrolysis products were analyzed by HPLC-MS. A major hydrolysis product was isolated by alumina oxide column chromatography, and identified by 1H and 13C-NMR spectra.
RESULTHPLC-MS analysis shows that the major hydrolysis products are benzoylaconine and aconine. The hydrolysis can mostly be completed within 20 hours.
CONCLUSIONDiester aconitum alkaloid can be changed to monoester aconitum and aconine alkaloids. Under the controled condition benzoylaconine is a major hydrolysis products.
