Effect of Bushen Yiqi Hexue recipe on endometrial P21 expression of embryo implantation dysfunctional mice.
- Author:
Dong-Mei HUANG
1
;
Guang-Yin HUANG
;
Li-Jun XU
;
Ming-Min ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cyclin-Dependent Kinase Inhibitor p21; metabolism; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Embryo Implantation; drug effects; physiology; Endometrium; metabolism; Female; Immunoblotting; Immunohistochemistry; Mice; Plants, Medicinal; chemistry; Proliferating Cell Nuclear Antigen; metabolism
- From: China Journal of Chinese Materia Medica 2007;32(20):2152-2155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Bushen Yiqi Hexue recipe on endometrial P21 and PCNA expression of embryo implantation dysfunctional mice.
METHODThe expression of P21 protein was analyzed by means of immunoblot and immunohistochemical method. The expression of PCNA protein was analyzed by means of immunohistochemical method.
RESULTThe expression and disappearance of P21 and PCNA protein in endometrium of embryo implantation dysfunctional mice lagged behind in a temporal and cell specific manner. Bushenyiqihexue recipe could improve the expression of P21 and PCNA protein in a temporal and cell specific manner, and then improve the decidual reaction of endometrium of embryo implantation dysfunctional mice.
CONCLUSIONImproving the expression of P21 and PCNA protein in endometrium and eventually regulating endometrium decidual reaction is one of the mechanisms of improved embryo implantaion by Bushen Yiqi Hexue recipe.
