Effect of total saponins of Rubus parviflolius (TSRP) on change of hydrated amount and blood-brain barrier in rats during focal cerebral ischemic/reperfusion.
- Author:
Ji-Sheng WANG
1
;
Zong-Yin QIU
;
Hui-Zhi LI
;
Yong-Peng XIA
;
Cheng-Lin ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood-Brain Barrier; drug effects; Brain Edema; drug therapy; etiology; pathology; Brain Ischemia; complications; Infarction, Middle Cerebral Artery; complications; Male; Phytotherapy; Plants, Medicinal; chemistry; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; complications; Rosaceae; chemistry; Saponins; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2007;32(20):2166-2169
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of total saponins of Rubus parviflolius (TSRP) on brain edema and blood brain barrier in rats.
METHODThe model of local cerebral ischemia was established in rats by reversible inserting a nylon thread into the anterior cerebral artery through the internal carotid artery brain hydrated amount and content change of Evan' s blue (EB) in cortex subjected to 2h middle cererbral artery occlusion (MACO) followed by 6 h, 24 h, 48 h, 72 h reperfusion and effect of TSRP. penetrability of blood brain-barrier (BBB) the index includes brain hydrated amount and penetrability of blood brain-barrier BBB.
RESULTCom- pared with I/R group. Both brain hydrated amount and the EB content decreased significantly in TSRP groups on the 6 h, 24 h, 48 h, 72 h of reperfusion after 2 hour of cerebral ischemia induced by MACO model.
CONCLUSIONTSRP could decrease brain hydrated amount and markedly lower permeability of blood-brain barrier subjected to 2 h MACO followed by 24 h reperfusion, and this may be a mechanism of TSRP alleviating brain edema during I/R.
