Effect of Danxiongfang and its components on experimental liver injury models induced by CCl4 in mice.
- Author:
Xiao-Rong LI
1
;
Li-Juan WANG
;
Yu-Hang LI
;
Yan-Xia XU
;
Yi CHEN
;
Jin-Xiu RUAN
;
Ming XUE
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Ligusticum; chemistry; Liver; drug effects; metabolism; pathology; Liver Diseases; blood; prevention & control; Male; Malondialdehyde; metabolism; Mice; Mice, Inbred ICR; Phytotherapy; Plants, Medicinal; chemistry; Protective Agents; isolation & purification; pharmacology; Salvia miltiorrhiza; chemistry; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2007;32(20):2177-2181
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe study investigates the protective effect on liver of Danxionfang and its components.
METHODMice are injected with CCl4 to establish liver injured model. ALT, AST, serum albumin, globulin in serum and SOD, MDA in liver and liver histological changes were measured to confirm the ability of protecting liver of Danxiongfang.
RESULTThe results show Danxiongfang can inhibit obviously the abnormal increase of ALT, AST in serum and MDA in liver, enhance SOD activity in liver, total protein, albumin, globulin in serum, and decrease liver pathological changes, which suggests Danxiongfang can protect injured liver induced by CCl4.
CONCLUSIONDanxiongfang showed powerful protective effect against liver damage induced by CCl4.
